🩸 Endocrine

Type 2 Diabetes

Chronic high blood glucose from insulin resistance and relative insulin deficiency.

Overview

Type 2 diabetes is a chronic metabolic condition. Good control prevents eye, kidney, nerve and cardiovascular complications.

Symptoms

  • Often none in early disease
  • Thirst, frequent urination
  • Fatigue
  • Recurrent infections
  • Blurred vision

Risk factors

  • Overweight
  • Family history
  • Physical inactivity
  • Gestational diabetes
  • PCOS
  • South Asian / African heritage

Causes

  • Insulin resistance with progressive beta-cell decline

🚨 Red flags — seek urgent care

  • Vomiting with high glucose
  • Rapid breathing, fruity breath (DKA)
  • Confusion or drowsiness

When to seek care

  • HbA1c rising despite therapy
  • Persistent hypoglycemia
  • Foot ulcers or vision change

Diagnosis

  • HbA1c ≥48 mmol/mol (6.5%) on two occasions if asymptomatic, or one if symptomatic
  • Fasting plasma glucose ≥7.0 mmol/L or random ≥11.1 mmol/L with symptoms
  • OGTT 2-h ≥11.1 mmol/L where indicated
  • Baseline: BP, lipids, U&E, eGFR, urine ACR, foot exam, retinal screening referral

Treatment

  • Lifestyle first: structured education (DESMOND), weight loss (≥5%), Mediterranean / low-carb diets, 150 min/week activity
  • First-line: metformin (standard-release, titrated); add SGLT2 inhibitor early if CV/renal disease
  • Intensification: GLP-1 receptor agonist, DPP-4, sulfonylurea or pioglitazone based on profile
  • Insulin where HbA1c remains above target despite oral therapy
  • Targets: HbA1c 48–53 mmol/mol; BP <140/80 (<130/80 if end-organ damage); statin for CV risk

Prevention

  • Maintain healthy weight; address central adiposity
  • Regular physical activity (mix of aerobic and resistance)
  • Mediterranean / low-glycaemic diet, limit ultra-processed foods
  • Smoking cessation
  • Annual review for high-risk groups (family history, gestational diabetes, ethnicity)

Complications

  • Cardiovascular disease — leading cause of mortality
  • Diabetic retinopathy (commonest cause of working-age blindness)
  • Diabetic kidney disease and end-stage renal failure
  • Peripheral neuropathy, foot ulceration, amputation
  • Increased infection risk, NAFLD, cognitive decline

Education & self-care

Annual eye, foot and kidney checks, plus cardiovascular risk management, are as important as glucose control itself.

Frequently asked questions

Can it be reversed?

Significant weight loss early in disease can induce remission for many patients.

Will I need insulin?

Many patients eventually do, but newer non-insulin therapies have delayed this for years for many.

Can type 2 diabetes be reversed?

Yes — substantial weight loss (typically 10–15 kg) achieved through low-calorie diets or bariatric surgery can put many people into long-term remission, especially within the first 6 years of diagnosis.

Why are SGLT2 inhibitors and GLP-1 drugs now preferred?

Beyond glucose control, they reduce cardiovascular events, heart failure and kidney decline, and many also produce weight loss. Guidelines increasingly recommend them earlier in treatment.

What HbA1c should I aim for?

A common target is HbA1c 48–53 mmol/mol (6.5–7.0%), individualised by age, frailty, hypoglycaemia risk and life expectancy. Looser targets are appropriate in older or frail patients.

Medically reviewed by Dr. Handel Emery, MD, FRCP (UK) · Last reviewed 2026-06-08